LDN and weight loss

Can LDN (low dose naltrexone) Help with Weight Loss?

August 23, 2021 By , , , , , , , , , ,

LDN and weight lossLDN, or low dose naltrexone can actually help SOME people lose weight.  The mechanism of actions may be multi-factorial.  However, this does not mean that LDN is a miracle weight loss med at all. In fact, it is not fully understood why it works so well for many people, while others may not have any noticeable effects. I find that my auto-immune  hypothyroid patients do benefit from using LDN for weight loss if they are not taking any medications that could interact with LDN.  LDN is used as part of our medical weight loss program called SYNERGYrx. 

History of Naltrexone and Low Dose Naltrexone

Naltrexone is used today as an opioid agonist in high doses.  It is also used to treat opioid induced constipation and to block the impact of opioids in the body.

In smaller doses, also known as low dose naltrexone, the medication has some mechanisms of action that have shown to be helpful in treating various conditions including chronic pain, autoimmune disease, and even metabolic damage and weight loss resistance. Low dose naltrexone is becoming more widely used in the treatment of many health conditions today.

Does LDN help with Weight Loss?

The truth is not very clear. Some studies show it to be helpful and some studies do not. It lies somewhere in the middle. In my clinical practice, I have seen it help many/most of my patients that I choose to put on LDN but not all. I am also selective about who I put on this medication and often like to have another helpful reason to utilize LDN.

There are many studies that show both Naltrexone and low dose naltrexone (LDN) to be capable of helping the body lower insulin levels. Naltrexone and low dose naltrexone have both also been shown to reduce inflammation in the body. Perhaps a combination of these effects help the body to have less hunger signaling and potential weight loss.

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